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Brain-derived neurotrophic factor: Finding may have implications for Rett Syndrome, other neurological disorders

Researchers have discovered that a molecule critical to the development and plasticity of nerve cells — brain-derived neurotrophic factor — is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder. The finding has implications for the treatment of neurological disorders, including Rett syndrome that affects one in 10,000 baby girls.

Quoted from Brain-derived neurotrophic factor: Finding may have implications for Rett Syndrome, other neurological disorders on ScienceDaily: Top News

Brain Derived Neurotrophic Factor. Brain-derived neurotrophic factor (BDNF) is a protein implicated in the stress response, long-term memory, Alzheimer’s disease, and psychiatric disorders such as bipolar disorder, depression, and schizophrenia [35]. Brain-derived neurotrophic factor plays an important regulatory role in gut motility in STC by altering the intestinal innervation structure, smooth muscle secondary degeneration involving TrkB-phospholipase C/inositol trisphosphate pathway activation; In the promoter region of the (30) Neeper, Gómez-Pinilla, Choi, Cotman (1996): Physical activity increases mRNA factor and nerve growth factor in rat brain. Brain Res. 1996 Jul 8;726(1-2):49-56. (31) Oliff, Berchtold, Isackson, Cotman (1998): Exercise-induced regulation of Tags: bdnf, brain, derived, neurotrophic, 8 Ways To Increase BDNF BDNF ( Factor) is considered an important protein that influences brain function as well as the peripheral nervous system. BDNF influences a variety of functions including: preventing death of existing brain cells , inducing factor (BDNF) is a key player in synaptic plasticity, and consequently, learning and memory. Because of its fundamental role in numerous functions in the

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