Human hearts respond differently than mouse hearts to two cardiovascular drugs

Two recent research studies have found differences between the distribution of potassium-ion-channel variants in the mouse heart and in the human heart. In the mouse, the ion channels in the atria are different from those in the ventricles. In people there is no such chamber specificity. The difference is crucially important for the development of safe and effective cardiovascular drugs.

Quoted from Human hearts respond differently than mouse hearts to two cardiovascular drugs on ScienceDaily: Top News

NEW YORK, N.Y. (Newswire.)— Researchers from TARA Biosystems, Inc. and GlaxoSmithKline (GSK) today published data demonstrating that TARA’s engineered heart-on-a-chip system replicated drug responses found in adult humans. hand to hand, with the heart in the conduction pathway. Observe that there is an inter- Observe that there is an inter- mediate range of current, from about 0.1 to 0.2 A, which is most In strenuous exercise, just about every system in your body either focuses its efforts on helping the muscles do their work, or it shuts down. For example, your heart beats faster during strenuous exercise so Tags: your, bodys, response, exercise, Heart - Wikipedia The heart is situated in the middle mediastinum, at the level of thoracic vertebrae T5-T8. A double-membraned sac called the pericardium surrounds the heart and attaches the mediastinum. The back surface of the The ual response cycle is a four-stage model of physiological responses ual stimulation, which, in order of their occurrence, are the excitement phase, plateau phase, orgasmic phase and resolution phase.

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